Role of calcium permeable channels in dendritic cell migration

Abstract

Calcium ion (Ca²⁺) is an essential second messenger involved in multiple cellular and subcellular processes. Ca²⁺ can be released and sensed globally or locally within cells, providing complex signals of variable amplitudes and time-scales. The key function of Ca²⁺ in the regulation of acto-myosin contractility has provided a simple explanation for its role in the regulation of immune cell migration. However, many questions remain, including the identity of the Ca²⁺ stores, channels and upstream signals involved in this process. Here, we focus on dendritic cells (DCs), because their immune sentinel function heavily relies on their capacity to migrate within tissues and later on between tissues and lymphoid organs. Deciphering the mechanisms by which cytoplasmic Ca²⁺ regulate DC migration should shed light on their role in initiating and tuning immune responses.