Targeting Molecular Recognition: Exploring the Dual Role of Functional Pseudoprolines in the Design of SH3 Ligands

Gabriele Tuchscherer; Daniel Grell; Yoshiro Tatsu; Patricia Durieux; Jimena Fernandez-Carneado; Beatrice Hengst; Christian Kardinal; Stephan Feller

doi:10.1002/1521-3773(20010803)40:15<2844::AID-ANIE2844>3.0.CO;2-F

Targeting Molecular Recognition: Exploring the Dual Role of Functional Pseudoprolines in the Design of SH3 Ligands

Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2844-2848. doi: 10.1002/1521-3773(20010803)40:15<2844::AID-ANIE2844>3.0.CO;2-F.

Authors

Gabriele Tuchscherer¹, Daniel Grell¹, Yoshiro Tatsu¹, Patricia Durieux¹, Jimena Fernandez-Carneado¹, Beatrice Hengst¹, Christian Kardinal², Stephan Feller²

Affiliations

¹ Institut für Organische Chemie Universität Lausanne BCH-Dorigny, 1015 Lausanne (Switzerland) Fax: (+41) 21-692-3955.
² Labor für Molekulare Onkologie, MSZ Universität Würzburg 97078 Würzburg (Germany) Fax: (+49) 931-201-3835.

PMID: 29712001
DOI: 10.1002/1521-3773(20010803)40:15<2844::AID-ANIE2844>3.0.CO;2-F

Abstract

Pseudoprolines (ΨPro) have been developed as tools for inducing bioactive conformations that allow for optimal spatial complementation in protein-protein interactions. This dual function of ΨPro was explored for tuning proline-rich peptides as potent ligands for SH3 domains.

Keywords: helical structures; ligand design; molecular recognition; protein-ligand interactions; pseudoprolines.