Functional Molecular Thin Films: Topological Templates for the Chemoselective Ligation of Antigenic Peptides to Self-Assembled Monolayers

Lukas Scheibler; Pascal Dumy; Mila Boncheva; Kirsten Leufgen; Hans-Jörg Mathieu; Manfred Mutter; Horst Vogel

doi:10.1002/(SICI)1521-3773(19990301)38:5<696::AID-ANIE696>3.0.CO;2-L

Functional Molecular Thin Films: Topological Templates for the Chemoselective Ligation of Antigenic Peptides to Self-Assembled Monolayers

Angew Chem Int Ed Engl. 1999 Mar 1;38(5):696-699. doi: 10.1002/(SICI)1521-3773(19990301)38:5<696::AID-ANIE696>3.0.CO;2-L.

Authors

Lukas Scheibler¹, Pascal Dumy¹, Mila Boncheva², Kirsten Leufgen², Hans-Jörg Mathieu³, Manfred Mutter¹, Horst Vogel²

Affiliations

¹ Institute of Organic Chemistry, University of Lausanne (Switzerland).
² LCPPM, Institute of Physical Chemistry, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne (Switzerland), Fax: (+41) 21-693-6190.
³ LMCH, Institute of Material Sciences, EPFL (Switzerland).

PMID: 29711537
DOI: 10.1002/(SICI)1521-3773(19990301)38:5<696::AID-ANIE696>3.0.CO;2-L

Abstract

The combination of self-assembly and regioselective surface chemistry has made it possible to immobilize peptide recognition sites 1 on a template attached to a gold surface. Each of the seven individual reaction steps, including the final functional biomolecular recognition, was controlled in situ with surface-sensitive detection techniques. The presented strategy is of general importance for the formation of complex supramolecular structures with biologically interesting functionalities at the interfaces.

Keywords: IR spectroscopy; Molecular recognition; Surface chemistry; Template synthesis; Thin films.