ESI Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (ESI-FT-ICR-MS): A Rapid High-Resolution Analytical Method for Combinatorial Compound Libraries

Tilmann B Walk; Axel W Trautwein; Hartmut Richter; Günther Jung

doi:10.1002/(SICI)1521-3773(19990614)38:12<1763::AID-ANIE1763>3.0.CO;2-#

ESI Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (ESI-FT-ICR-MS): A Rapid High-Resolution Analytical Method for Combinatorial Compound Libraries

Angew Chem Int Ed Engl. 1999 Jun 14;38(12):1763-1765. doi: 10.1002/(SICI)1521-3773(19990614)38:12<1763::AID-ANIE1763>3.0.CO;2-#.

Authors

Tilmann B Walk¹, Axel W Trautwein¹, Hartmut Richter¹, Günther Jung¹

Affiliation

¹ Institut für Organische Chemie der Universität, Auf der Morgenstelle 18, D-72076 Tübingen (Germany), Fax: (+49) 7071-29-5560.

Abstract

The direct determination of the elemental compositions of the components of compound collections from combinatorial chemistry is achieved by ESI-FT-ICR mass spectrometry. Coupling with HPLC opens up a new dimension in high-resolution, informative analysis. The improved resolution of ESI-FT-ICR mass spectrometry in comparison to quadrupole mass spectrometry in the measurement of a compound obtained by solid-phase synthesis is illustrated.

Keywords: Analytical methods; Combinatorial chemistry; HPLC-MS coupling; Mass spectrometry.