Bacterial Degradation of Quinoline and Derivatives-Pathways and Their Biocatalysts

Susanne Fetzner; Barbara Tshisuaka; Franz Lingens; Reinhard Kappl; Jürgen Hüttermann

doi:10.1002/(SICI)1521-3773(19980316)37:5<576::AID-ANIE576>3.0.CO;2-L

Bacterial Degradation of Quinoline and Derivatives-Pathways and Their Biocatalysts

Angew Chem Int Ed Engl. 1998 Mar 16;37(5):576-597. doi: 10.1002/(SICI)1521-3773(19980316)37:5<576::AID-ANIE576>3.0.CO;2-L.

Authors

Susanne Fetzner¹, Barbara Tshisuaka², Franz Lingens², Reinhard Kappl³, Jürgen Hüttermann³

Affiliations

¹ Fachbereich Biologie der Universität, Postfach 2503, D-26111 Oldenburg (Germany), Fax.: (+49) 441-798-3250.
² Institut für Mikrobiologie der Universität Hohenheim, D-70593 Stuttgart (Germany).
³ Fachrichtung Biophysik der Universität des Saarlandes, D-66421 Homburg (Saar), (Germany).

PMID: 29711093
DOI: 10.1002/(SICI)1521-3773(19980316)37:5<576::AID-ANIE576>3.0.CO;2-L

Abstract

A series of interesting enzymes were discovered during investigations on the degradation of quinoline by microorganisms. These include the molybdenum-containing hydroxylases that catalyze the transformation 1→2 and the unusual 2,4-dioxygenases that catalyze the reaction 3→4. The application of the hydroxylases may even be interesting in industry, because several quinoline derivatives are used as pharmaceuticals or agrochemicals.

Keywords: Enzyme catalysis; Enzymes; Heterocycles; Metabolism; Quinoline.

Publication types

Review