OGG1 Ser326Cys polymorphism, HIV, obesity and air pollution exposure influences adverse birth outcome susceptibility, within South African Women

Samantha M Anderson; Rajen N Naidoo; Prithiksha Ramkaran; Kareshma Asharam; Sheena Muttoo; Anil A Chuturgoon

doi:10.1016/j.reprotox.2018.04.012

OGG1 Ser326Cys polymorphism, HIV, obesity and air pollution exposure influences adverse birth outcome susceptibility, within South African Women

Reprod Toxicol. 2018 Aug:79:8-15. doi: 10.1016/j.reprotox.2018.04.012. Epub 2018 Apr 27.

Authors

Samantha M Anderson¹, Rajen N Naidoo², Prithiksha Ramkaran¹, Kareshma Asharam², Sheena Muttoo², Anil A Chuturgoon³

Affiliations

¹ Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, Durban, 4041, South Africa.
² Discipline of Occupational and Environmental Health, School of Nursing and Public Health, College of Health Science, University of KwaZulu-Natal, Durban, 4041, South Africa.
³ Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, Durban, 4041, South Africa. Electronic address: chutur@ukzn.ac.za.

PMID: 29709520
DOI: 10.1016/j.reprotox.2018.04.012

Abstract

The global HIV and obesity epidemics are major public health concerns; particularly as both are associated with increased risk of adverse birth outcomes. Despite extensive research, their combined effect, in terms of birth outcomes, has not been investigated. A single-nucleotide polymorphism (SNP) within 8-oxoguanine glycosylase 1 (OGG1) (Ser326Cys) has been suggested to affect body mass indices and therefore could predispose South African (SA) women to adverse effects of obesity. This study investigated the associations of OGG1 Ser326Cys SNP in relation to HIV and obesity on the susceptibility of low-birthweight (LBW) and pre-term birth (PTB) in SA women exposed to ambient air-pollution living in Durban. In our study population, the OGG1 SNP was associated with HIV and obesity. Wild-type (CC)-carrying patients had increased susceptibility for HIV-associated LBW and PTB. Co-morbid HIV and obese patients delivered neonates with decreased birthweights. Living within the heavily-polluted south-Durban and carrying the CC-genotype increased the risk for PTB within our study population.

Keywords: Air pollution; HIV; Low birthweight; OGG1 Ser326Cys polymorphism; Obesity; Pre-term birth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Air Pollution / adverse effects*
Comorbidity
DNA Glycosylases / genetics*
Environmental Exposure / adverse effects
Female
Genetic Predisposition to Disease*
Genotype
HIV Infections / epidemiology
HIV Infections / genetics*
Humans
Infant, Low Birth Weight*
Infant, Newborn
Male
Obesity / epidemiology
Obesity / genetics*
Polymorphism, Single Nucleotide
Pregnancy
Premature Birth / epidemiology
Premature Birth / genetics*
Risk Factors
South Africa / epidemiology
Young Adult

Substances

DNA Glycosylases
oxoguanine glycosylase 1, human