Development of new hepatitis E vaccines

Yufeng Cao; Zhenhong Bing; Shiyu Guan; Zecai Zhang; Xinping Wang

doi:10.1080/21645515.2018.1469591

Development of new hepatitis E vaccines

Hum Vaccin Immunother. 2018;14(9):2254-2262. doi: 10.1080/21645515.2018.1469591. Epub 2018 Jun 18.

Authors

Yufeng Cao^{1

2}, Zhenhong Bing³, Shiyu Guan³, Zecai Zhang^{1

4}, Xinping Wang^{1

4}

Affiliations

¹ a College of Veterinary Medicine, Jilin University , Changchun , Jilin , PR China.
² b Changchun Institute of Biological Products Co. Ltd. , Changchun , Jilin , PR China.
³ c Changchun Institute of Biological Products , Changchun , Jilin , PR China.
⁴ d Key laboratory for Zoonosis , Ministry of Education, and Institute for Zoonosis of Jilin University , Changchun , Jilin , PR China.

Abstract

Hepatitis E virus (HEV) infection is an emerging zoonotic disease posing a severe threat to public health in the world, especially to pregnant women. Currently, no specific treatments are available for HEV infection. Therefore, it is crucial to develop vaccine to prevent this infection. Although several potential candidate vaccines against HEV have been studied for their immunogenicity and efficacy, only Hecolin® which is developed by Xiamen Innovax Biotech Co., Ltd. and approved by China Food and Drug Administration (CFDA) in 2012, is the licensed HEV vaccine in the world so far. Extensive studies on safety, immunogenicity and efficacy in phase III clinical trials have shown that Hecolin® is a promising vaccine for HEV prevention and control. In this article, the advances on HEV vaccine development and research are briefly reviewed.

Keywords: Advance; HEV; Hepatitis E; Vaccine.

Publication types

Historical Article
Research Support, Non-U.S. Gov't
Review

MeSH terms

China
Clinical Trials, Phase III as Topic
Disease Transmission, Infectious / prevention & control*
Drug Development / history
Hepatitis E / prevention & control*
Hepatitis E virus / immunology*
History, 21st Century
Humans
Treatment Outcome
Vaccines, Synthetic / administration & dosage
Vaccines, Synthetic / adverse effects
Vaccines, Synthetic / immunology*
Vaccines, Synthetic / isolation & purification
Viral Hepatitis Vaccines / administration & dosage
Viral Hepatitis Vaccines / adverse effects
Viral Hepatitis Vaccines / immunology*
Viral Hepatitis Vaccines / isolation & purification

Substances

Vaccines, Synthetic
Viral Hepatitis Vaccines
hecolin

Grants and funding

This study was supported by the National Key Research and Development Program of China (2017YFD0500104, 2016YFD0500904), and the National Natural Science Foundation of China (31572531).