Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes

Olga Taraschenko; Swetha Pedavally; Kaeli K Samson; Mark J Puccioni; Deepak Madhavan

doi:10.1016/j.ebcr.2017.12.001

Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes

Epilepsy Behav Case Rep. 2017 Dec 8:9:12-18. doi: 10.1016/j.ebcr.2017.12.001. eCollection 2018.

Authors

Olga Taraschenko¹, Swetha Pedavally¹, Kaeli K Samson², Mark J Puccioni³, Deepak Madhavan¹

Affiliations

¹ Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
² Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, United States.
³ Division of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, United States.

Abstract

Corpus callosotomy (CC) is used in patients with drug-resistant seizures who are not candidates for excisional surgery and failed neurostimulation. We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired awareness but did not alter outcomes for generalized tonic-clonic or tonic seizures. Invasive EEG prior to CC did not refine the prediction of postsurgical seizure outcomes in patients with inconclusive scalp EEG.

Keywords: Corpus callosotomy; Epilepsy surgery; Intracranial EEG; Refractory seizures.

Publication types

Case Reports