The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?

Histol Histopathol. 2018 Nov;33(11):1135-1149. doi: 10.14670/HH-11-993. Epub 2018 Apr 24.

Abstract

A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development.

Publication types

  • Review

MeSH terms

  • Chagas Disease* / complications
  • Chagas Disease* / physiopathology
  • Esophageal Achalasia* / complications
  • Esophageal Achalasia* / physiopathology
  • Esophageal Neoplasms* / complications
  • Esophageal Neoplasms* / diagnosis
  • Esophageal Neoplasms* / epidemiology
  • Esophageal Squamous Cell Carcinoma* / complications
  • Esophageal Squamous Cell Carcinoma* / diagnosis
  • Esophageal Squamous Cell Carcinoma* / epidemiology
  • Female
  • Humans
  • Male
  • Papillomavirus Infections* / complications
  • Papillomavirus Infections* / physiopathology
  • Risk Factors
  • Trypanosoma cruzi*