Abstract
A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development.
MeSH terms
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Chagas Disease* / complications
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Chagas Disease* / physiopathology
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Esophageal Achalasia* / complications
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Esophageal Achalasia* / physiopathology
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Esophageal Neoplasms* / complications
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Esophageal Neoplasms* / diagnosis
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Esophageal Neoplasms* / epidemiology
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Esophageal Squamous Cell Carcinoma* / complications
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Esophageal Squamous Cell Carcinoma* / diagnosis
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Esophageal Squamous Cell Carcinoma* / epidemiology
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Female
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Humans
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Male
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Papillomavirus Infections* / complications
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Papillomavirus Infections* / physiopathology
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Risk Factors
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Trypanosoma cruzi*