HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians

Hum Immunol. 2018 Jul;79(7):527-529. doi: 10.1016/j.humimm.2018.04.012. Epub 2018 Apr 21.

Abstract

We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on a Next Generation Sequencing platform. Data were analyzed using Arlequin and Pypop software. No significant deviations from Hardy-Weinberg Equilibrium were noted at any of the loci studied. We discuss the representability for the Norwegian population and argue that the presented HLA data could serve as a Norwegian reference panel.

Keywords: HLA; HLA allele frequency; Haplotype; Reference panel.

MeSH terms

  • Bone Marrow Transplantation
  • Gene Frequency
  • Genotype
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-C Antigens / genetics*
  • HLA-DP beta-Chains / genetics*
  • HLA-DQ beta-Chains / genetics*
  • HLA-DRB1 Chains / genetics*
  • Haplotypes
  • Healthy Volunteers
  • High-Throughput Nucleotide Sequencing
  • Histocompatibility Testing
  • Humans
  • Norway
  • Registries*
  • Tissue Donors

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • HLA-DP beta-Chains
  • HLA-DPB1 antigen
  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DRB1 Chains