Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer

Zhilan Chen; Yingyan Han; Chengwen Song; Huafang Wei; Ying Chen; Kecheng Huang; Shuang Li; Ding Ma; Shixuan Wang; Jing Wang; Qiping Lu

doi:10.18632/oncotarget.23839

Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer

Oncotarget. 2017 Dec 16;9(24):17141-17148. doi: 10.18632/oncotarget.23839. eCollection 2018 Mar 30.

Authors

Zhilan Chen^#¹, Yingyan Han^#², Chengwen Song¹, Huafang Wei¹, Ying Chen¹, Kecheng Huang², Shuang Li², Ding Ma², Shixuan Wang², Jing Wang¹, Qiping Lu³

Affiliations

¹ Department of Obstetrics and Gynecology, Wuhan General Hospital of People's Liberation Army of China, Wuhan, Hubei, China.
² Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of General Surgery, Wuhan General Hospital of People's Liberation Army of China, Wuhan, Hubei, China.

^# Contributed equally.

Abstract

In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1.61, 95% CI: 1.02-2.55, P = 0.042; I² = 10.1%, P = 0.292; n = 99), low miR-145 expression (HR = 1.70, 95% CI: 1.29-2.24, P < 0.001; I² = 0%, P = 0.560; n = 193) and high miR-196 expression (HR = 0.28, 95% CI: 0.15-0.52, P < 0.001; I² = 0%, P = 0.950, n = 197). This makes microRNAs such as miR-125, miR-145 and miR-196 potential prognostic biomarkers in cervical cancer.

Keywords: cervical cancer; meta-analysis; miRNA; prognosis.