Computer-Aided Diagnosis of Acute Lymphoblastic Leukaemia

Comput Math Methods Med. 2018 Feb 28:2018:6125289. doi: 10.1155/2018/6125289. eCollection 2018.

Abstract

Leukaemia is a form of blood cancer which affects the white blood cells and damages the bone marrow. Usually complete blood count (CBC) and bone marrow aspiration are used to diagnose the acute lymphoblastic leukaemia. It can be a fatal disease if not diagnosed at the earlier stage. In practice, manual microscopic evaluation of stained sample slide is used for diagnosis of leukaemia. But manual diagnostic methods are time-consuming, less accurate, and prone to errors due to various human factors like stress, fatigue, and so forth. Therefore, different automated systems have been proposed to wrestle the glitches in the manual diagnostic methods. In recent past, some computer-aided leukaemia diagnosis methods are presented. These automated systems are fast, reliable, and accurate as compared to manual diagnosis methods. This paper presents review of computer-aided diagnosis systems regarding their methodologies that include enhancement, segmentation, feature extraction, classification, and accuracy.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Bayes Theorem
  • Cluster Analysis
  • Computational Biology
  • Diagnosis, Computer-Assisted / methods*
  • Diagnosis, Computer-Assisted / statistics & numerical data
  • Fractals
  • Fuzzy Logic
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Lymphocytes / pathology
  • Models, Statistical
  • Neural Networks, Computer
  • Pattern Recognition, Automated
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Support Vector Machine