A Novel Regulator of Type II Diabetes: MicroRNA-143

Trends Endocrinol Metab. 2018 Jun;29(6):380-388. doi: 10.1016/j.tem.2018.03.019. Epub 2018 Apr 18.

Abstract

MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.

Keywords: ORP8; T2DM; exercise intervention; insulin resistance; miR-143.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / therapy*
  • Exercise Therapy
  • Humans
  • Insulin Resistance / genetics
  • Insulin Resistance / physiology
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Receptors, Steroid / genetics
  • Receptors, Steroid / metabolism

Substances

  • MIRN143 microRNA, human
  • MicroRNAs
  • Receptors, Steroid
  • oxysterol binding protein