Abstract
Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.
Copyright © 2018 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Active Transport, Cell Nucleus*
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Amyotrophic Lateral Sclerosis / therapy
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Animals
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Cell Nucleus / metabolism
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DNA-Binding Proteins / metabolism
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Humans
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Karyopherins / metabolism*
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Models, Biological
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Neurodegenerative Diseases / therapy
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Proteome
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RNA / metabolism
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RNA-Binding Protein FUS / metabolism*
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RNA-Binding Proteins / metabolism
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Receptors, Cytoplasmic and Nuclear / metabolism
Substances
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DNA-Binding Proteins
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Karyopherins
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Proteome
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RNA-Binding Protein FUS
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RNA-Binding Proteins
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Receptors, Cytoplasmic and Nuclear
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RNA