Beyond the Transport Function of Import Receptors: What's All the FUS about?

Cell. 2018 Apr 19;173(3):549-553. doi: 10.1016/j.cell.2018.04.002.

Abstract

Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus*
  • Amyotrophic Lateral Sclerosis / therapy
  • Animals
  • Cell Nucleus / metabolism
  • DNA-Binding Proteins / metabolism
  • Humans
  • Karyopherins / metabolism*
  • Models, Biological
  • Neurodegenerative Diseases / therapy
  • Proteome
  • RNA / metabolism
  • RNA-Binding Protein FUS / metabolism*
  • RNA-Binding Proteins / metabolism
  • Receptors, Cytoplasmic and Nuclear / metabolism

Substances

  • DNA-Binding Proteins
  • Karyopherins
  • Proteome
  • RNA-Binding Protein FUS
  • RNA-Binding Proteins
  • Receptors, Cytoplasmic and Nuclear
  • RNA