A Mechanosensitive GPCR that Detects the Bloody Force

Adam J Iliff; X Z Shawn Xu

doi:10.1016/j.cell.2018.04.001

A Mechanosensitive GPCR that Detects the Bloody Force

Cell. 2018 Apr 19;173(3):542-544. doi: 10.1016/j.cell.2018.04.001.

Authors

Adam J Iliff¹, X Z Shawn Xu²

Affiliations

¹ Life Sciences Institute and Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
² Life Sciences Institute and Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: shawnxu@umich.edu.

Abstract

Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Hearing
Ion Channels
Mechanoreceptors*
Proprioception
Touch*

Substances

Ion Channels

Grants and funding

R01 GM083241/GM/NIGMS NIH HHS/United States