The brassinosteroid-regulated transcription factors BZR1/BES1 function as a coordinator in multisignal-regulated plant growth

Qian-Feng Li; Jun Lu; Jia-Wen Yu; Chang-Quan Zhang; Jun-Xian He; Qiao-Quan Liu

doi:10.1016/j.bbagrm.2018.04.003

The brassinosteroid-regulated transcription factors BZR1/BES1 function as a coordinator in multisignal-regulated plant growth

Biochim Biophys Acta Gene Regul Mech. 2018 Jun;1861(6):561-571. doi: 10.1016/j.bbagrm.2018.04.003. Epub 2018 Apr 17.

Authors

Qian-Feng Li¹, Jun Lu², Jia-Wen Yu², Chang-Quan Zhang¹, Jun-Xian He³, Qiao-Quan Liu⁴

Affiliations

¹ Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou University, Yangzhou 225009, China; Co-Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province/Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou University, Yangzhou 225009, China.
² Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou University, Yangzhou 225009, China.
³ School of Life Sciences and State Key Laboratory of Agrobiotechnology, Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region. Electronic address: jxhe@cuhk.edu.hk.
⁴ Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou University, Yangzhou 225009, China; Co-Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province/Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou University, Yangzhou 225009, China. Electronic address: qqliu@yzu.edu.cn.

PMID: 29673687
DOI: 10.1016/j.bbagrm.2018.04.003

Abstract

BZR1 and BES1 are key transcription factors of brassinosteroid (BR) signaling and represent the integration node of numerous signaling cascades. Their direct target genes have been identified, and BZR1/BES1-DNA interactions have been experimentally verified. Importantly, BZR1/BES1 also integrate different growth and development events via direct protein-protein interactions. For instance, DELLAs, PIFs, ARF6, and PKL, all directly interact with BZR1/BES1, forming a BZR1/BES1-centered regulatory network to coordinate cell elongation. By dissecting various BZR1/BES1-mediated BR responses, the concept that BZR1/BES1 act as an integration hub in multisignal-regulated plant growth and development was developed. The regulation of BZR1/BES1 is dynamic and multifaceted, including phosphorylation status, activity, and stability. Moreover, certain epigenetic modification mechanisms are involved in BZR1/BES1's regulation of gene expression. Herein, we review recent advances in BZR1/BES1-mediated molecular connections between BR and other pathways, highlighting the central role of the BZR1/BES1 interactome in optimizing plant growth and development.

Keywords: BZR1/BES1; Brassinosteroid; Plant growth and development; Protein-protein interaction; Signaling crosstalk; Transcriptional regulation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Arabidopsis Proteins / genetics
Arabidopsis Proteins / metabolism*
DNA-Binding Proteins
Epigenesis, Genetic / physiology*
Gene Expression Regulation, Plant / physiology*
Gene Regulatory Networks / physiology*
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
Plant Physiological Phenomena*
Signal Transduction / physiology*

Substances

Arabidopsis Proteins
BZR1 protein, Arabidopsis
DNA-Binding Proteins
Nuclear Proteins