Symmetric Stem Cell Division at the Heart of Adult Neurogenesis

Violeta Silva-Vargas; Ana C Delgado; Fiona Doetsch

doi:10.1016/j.neuron.2018.04.005

Symmetric Stem Cell Division at the Heart of Adult Neurogenesis

Neuron. 2018 Apr 18;98(2):246-248. doi: 10.1016/j.neuron.2018.04.005.

Authors

Violeta Silva-Vargas¹, Ana C Delgado¹, Fiona Doetsch²

Affiliations

¹ Biozentrum, University of Basel, Basel CH-4056, Switzerland.
² Biozentrum, University of Basel, Basel CH-4056, Switzerland. Electronic address: fiona.doetsch@unibas.ch.

PMID: 29673477
DOI: 10.1016/j.neuron.2018.04.005

Abstract

Obernier et al. (2018) show that the primary mode of division of adult ventricular-subventricular zone (V-SVZ) neural stem cells is symmetric, with the majority generating two non-stem cell progeny, and a minority self-renewing. This discovery has important implications for understanding stem cell dynamics and adult neurogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Adult Stem Cells / physiology*
Animals
Cell Division / physiology*
Cell Lineage / physiology
Humans
Neural Stem Cells / physiology*
Neurogenesis / physiology*