The ability to support a replicator population in an extremely hostile environment is considered in a simple model of a prebiotic cell. We explore from a classical approach how the replicator viability changes as a function of the cell radius. The model includes the interaction between two different species: a substrate that flows from the exterior and a replicator that feeds on the substrate and is readily destroyed in the environment outside the cell. According to our results, replicators in the cell only exist when the radius exceeds some critical value [Formula: see text] being, in general, a function of the substrate concentration, the diffusion constant of the replicator species, and the reproduction rate coefficient. Additionally, the influence of other parameters on the replicator population is also considered. The viability of chemical replicators under such drastic conditions could be crucial in understanding the origin of the first primitive cells and the ulterior development of life on our planet. Key Words: Prebiotic cell-Chemical replicator-Environment-Reproduction rate. Astrobiology 18, 403-411.