Vaccinations in pediatric kidney transplant recipients

Pediatr Nephrol. 2019 Apr;34(4):579-591. doi: 10.1007/s00467-018-3953-z. Epub 2018 Apr 18.

Abstract

Pediatric kidney transplant (KT) candidates should be fully immunized according to routine childhood schedules using age-appropriate guidelines. Unfortunately, vaccination rates in KT candidates remain suboptimal. With the exception of influenza vaccine, vaccination after transplantation should be delayed 3-6 months to maximize immunogenicity. While most vaccinations in the KT recipient are administered by primary care physicians, there are specific schedule alterations in the cases of influenza, hepatitis B, pneumococcal, and meningococcal vaccinations; consequently, these vaccines are usually administered by transplant physicians. This article will focus on those deviations from the normal vaccine schedule important in the care of pediatric KT recipients. The article will also review human papillomavirus vaccine due to its special importance in cancer prevention. Live vaccines are generally contraindicated in KT recipients. However, we present a brief review of live vaccines in organ transplant recipients, as there is evidence that certain live virus vaccines may be safe and effective in select groups. Lastly, we review vaccination of pediatric KT recipients prior to international travel.

Keywords: Children; Immunization; Kidney; Kidney transplantation; Solid organ transplantation; Transplantation; Vaccination.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Age Factors
  • Child
  • Child, Preschool
  • Humans
  • Immunization Schedule
  • Immunocompromised Host
  • Immunosuppressive Agents / adverse effects
  • Infant
  • Kidney Transplantation* / adverse effects
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / immunology
  • Opportunistic Infections / prevention & control*
  • Papillomavirus Vaccines / administration & dosage
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Vaccination*
  • Vaccines / administration & dosage*
  • Vaccines / adverse effects
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Live, Unattenuated / administration & dosage

Substances

  • Immunosuppressive Agents
  • Papillomavirus Vaccines
  • Vaccines
  • Vaccines, Attenuated
  • Vaccines, Live, Unattenuated