Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: Review from a dermatologic perspective

Vieri Grandi; Maurizio Sessa; Luigi Pisano; Riccardo Rossi; Arturo Galvan; Riccardo Gattai; Moira Mori; Luana Tiradritti; Stefano Bacci; Giuliano Zuccati; Pietro Cappugi; Nicola Pimpinelli

doi:10.1016/j.pdpdt.2018.04.005

Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: Review from a dermatologic perspective

Photodiagnosis Photodyn Ther. 2018 Sep:23:119-131. doi: 10.1016/j.pdpdt.2018.04.005. Epub 2018 Apr 15.

Authors

Affiliations

¹ University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy. Electronic address: vieri.grandi@unifi.it.
² University of Campania "Luigi Vanvitelli", Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Via L. De Crecchio 7, Naples, Italy.
³ University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy.
⁴ Private Practice Dermatologist, C.M.R, Via S. Giovanni Bosco, 24, 36015, Schio, Italy.
⁵ University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Largo Brambilla 3, 50141, Florence, Italy.
⁶ Department of Clinical and Experimental Medicine, Research Unit of Histology and Embriology, University of Florence, 50141, Florence, Italy.

PMID: 29669264
DOI: 10.1016/j.pdpdt.2018.04.005

Abstract

Photodynamic Therapy is a procedure based on the interaction between a Photosensitizer, a light source with a specific wavelength and oxygen. The aim of this review is to provide a brief and updated analysis of scientific reports on the use of PDT with topical PS in the management of oncological, infectious, and inflammatory disorders involving mucosal and semimucosal areas, with a specific focus on diseases of dermatologic interest.

Keywords: Candidiasis, Oral; Eyelid diseases; Lichen Sclerosus et atrophicus, Lichen Planus, Oral; Off-label use; Photodynamic therapy.

Publication types

Review

MeSH terms

Anus Neoplasms / drug therapy
Anus Neoplasms / pathology
Autoimmune Diseases / drug therapy
Autoimmune Diseases / pathology
Eyelid Neoplasms / drug therapy
Eyelid Neoplasms / pathology
Female
Heat-Shock Proteins / biosynthesis
Humans
Infections / drug therapy
Infections / pathology
Inflammation / drug therapy
Inflammation / pathology
Mouth Diseases / drug therapy
Mouth Diseases / pathology
Neoplasms / drug therapy
Neoplasms / pathology
Neovascularization, Pathologic / drug therapy
Neovascularization, Pathologic / pathology
Paget Disease, Extramammary / drug therapy
Paget Disease, Extramammary / pathology
Photochemotherapy / methods*
Photosensitizing Agents / administration & dosage
Photosensitizing Agents / pharmacology*
Photosensitizing Agents / therapeutic use*
Singlet Oxygen / metabolism
Superoxides / metabolism
Up-Regulation

Substances

Heat-Shock Proteins
Photosensitizing Agents
Superoxides
Singlet Oxygen