A Hen in the Wolf Den: A Pathobiont Tale

Matteo M Guerrini; Alexis Vogelzang; Sidonia Fagarasan

doi:10.1016/j.immuni.2018.04.003

A Hen in the Wolf Den: A Pathobiont Tale

Immunity. 2018 Apr 17;48(4):628-631. doi: 10.1016/j.immuni.2018.04.003.

Authors

Matteo M Guerrini¹, Alexis Vogelzang¹, Sidonia Fagarasan²

Affiliations

¹ Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute,1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045 Kanagawa, Japan.
² Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute,1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045 Kanagawa, Japan. Electronic address: sidonia.fagarasan@riken.jp.

PMID: 29669247
DOI: 10.1016/j.immuni.2018.04.003

Abstract

Disruption of the gut microbiota is thought to contribute to disease onset in individuals with a genetic predisposition to autoimmunity. In a recent issue of Science, Manfredo Vieira et al. (2018) identify translocation of the gut commensal Enterococcus gallinarum into the liver as a trigger for the autoimmune disease systemic lupus erythematous.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Autoimmunity*
Chickens
Female
Gastrointestinal Microbiome
Humans
Mice
Wolves*