GoldiRunx and Remembering Cytotoxic Memory

Yohei Mikami; Yuka Kanno

doi:10.1016/j.immuni.2018.03.032

GoldiRunx and Remembering Cytotoxic Memory

Immunity. 2018 Apr 17;48(4):614-615. doi: 10.1016/j.immuni.2018.03.032.

Authors

Yohei Mikami¹, Yuka Kanno²

Affiliations

¹ Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kannoy@mail.nih.gov.

PMID: 29669241
DOI: 10.1016/j.immuni.2018.03.032

Abstract

The molecular basis for T cell memory differentiation remains elusive. Wang et al. (2018) identify Runx3 as an initiating transcription factor that specifies regulatory regions required for cytotoxic T cell (CTL) memory differentiation early after TCR signaling and constrains the ability of T-bet to drive terminal effector generation.

Published by Elsevier Inc.

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MeSH terms

Cell Differentiation
Chromatin*
Gene Expression Regulation
Memory
T-Lymphocytes, Cytotoxic*
Transcription Factors

Substances

Chromatin
Transcription Factors