Abstract
A new lupane triterpenoid, 23-O-trans-feruloylcylicodiscic acid (1), as well as four known analogues (2‒5), was isolated from the EtOAc fraction of Menyanthes trefoliata. The structure of compound 1 was elucidated on the basis of extensive spectroscopic analysis, including 2D NMR data. The structures of the known compounds were established by comparison of their spectroscopic data with that in the literature. Compounds 1, 2, and 4 exhibited certain anti-NO production activities.
Keywords:
Gentianaceae; anti-NO production; lupane triterpenoid.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Gentianaceae / chemistry*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Pentacyclic Triterpenes / chemistry*
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Pentacyclic Triterpenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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RAW 264.7 Cells
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Triterpenes / chemistry*
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Triterpenes / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Pentacyclic Triterpenes
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Plant Extracts
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Triterpenes
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Nitric Oxide