Lipoic acid (LA) is widely present in the body as a disulfide compound with an extensive biological activity and a strong antioxidant capacity. LA plays an antioxidant role by removing oxygen free radicals, chelating metal ions, and regenerating other antioxidants in the body. Recent studies have shown the effects of LA in the prevention or treatment of male reproductive disorders, such as idiopathic oligoasthenozoospermia, diabetes mellitus-induced erectile dysfunction and infertility, serious infection in the reproductive system, and reproductive system injuries caused by chemotherapeutic agents, ionizing radiation, environmental toxins, testicular ischemia reperfusion, excessive exercise, and so on.
硫辛酸（LA）享有“万能抗氧化剂”之称，在生物体内广泛存在，是一种具有广泛生物学活性的二硫化合物，具有很强的抗氧化活性。LA可以清除体内氧自 由基、螯合金属离子、再生体内其他抗氧化剂来发挥抗氧化作用。近年来研究发现，将LA应用于男性生殖健康问题的预防或治疗，如特发性弱精子症、糖尿病合并勃 起功能障碍及不育、生殖系统严重感染的治疗，预防化疗药物、电离辐射、环境毒物、睾丸缺血再灌注和剧烈运动等多种原因所致的生殖系统损伤，均取得良好的效 果。本文就LA在男性不育中的研究进展做一综述。.
Keywords: antioxidant; lipoic acid; male infertility; spermatozoa.