Coating with Microbial Hydrophobins: A Novel Approach to Develop Smart Drug Nanoparticles

Brahma N Singh; Braj R Singh; Vijai K Gupta; Ravindra N Kharwar; Lorenzo Pecoraro

doi:10.1016/j.tibtech.2018.03.006

Coating with Microbial Hydrophobins: A Novel Approach to Develop Smart Drug Nanoparticles

Trends Biotechnol. 2018 Nov;36(11):1103-1106. doi: 10.1016/j.tibtech.2018.03.006. Epub 2018 Apr 11.

Authors

Brahma N Singh¹, Braj R Singh², Vijai K Gupta³, Ravindra N Kharwar⁴, Lorenzo Pecoraro⁵

Affiliations

¹ Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001, India. Electronic address: bn.singh@nbri.res.in.
² Centre of Excellence in Materials Science (Nanomaterials), Z.H. College of Engineering & Technology, Aligarh Muslim University, Aligarh 202002, India; Current address: TERI-Deakin Nanobiotechnology Centre, TERI Gram, The Energy and Resources Institute, Gual Pahari, Gurugram-Faridabad Road, Gurugram 122 001, Haryana, India.
³ ERA Chair of Green Chemistry, Department of Chemistry and Biotechnology, Tallinn University of Technology, 12618 Tallinn, Estonia. Electronic address: vijai.gupta@ttu.ee.
⁴ Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi 221005 India.
⁵ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China.

PMID: 29655604
DOI: 10.1016/j.tibtech.2018.03.006

Abstract

Microbial hydrophobin (MH)-based surface coating is emerging as a novel protein engineering approach for drug nanoparticles to enhance the solubility and stability of therapeutic agents. These hydrophobins are amphiphilic proteins that can form self-assembled monolayers on hydrophobic materials and can coat nanoparticles for efficient drug delivery.

Keywords: coating; drug delivery; drug nanoparticles; microbial hydrophobins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / chemistry*
Bacterial Proteins / metabolism
Carrier Proteins / chemistry*
Carrier Proteins / metabolism
Drug Carriers / chemistry*
Drug Carriers / pharmacokinetics
Drug Delivery Systems*
Drug Stability
Fungal Proteins / chemistry*
Fungal Proteins / metabolism
Nanoparticles / chemistry*
Solubility
Surface-Active Agents / chemistry*
Surface-Active Agents / metabolism
Technology, Pharmaceutical / methods

Substances

Bacterial Proteins
Carrier Proteins
Drug Carriers
Fungal Proteins
Surface-Active Agents