Emerging landscape of circular RNAs in lung cancer

Cancer Lett. 2018 Jul 28:427:18-27. doi: 10.1016/j.canlet.2018.04.006. Epub 2018 Apr 11.

Abstract

Lung cancer, the leading cause of cancer deaths worldwide, is characterized with malignant cell growth. Advances in next-generation sequencing has helped us further understand RNA and identify novel circular RNAs (circRNAs) that may be useful in the early diagnosis and treatment of lung cancer. Similar to other noncoding RNAs, circRNAs present diverse biological functions in normal and disease states, including various types of cancers. This review focuses mainly on the poorly understood functions of circRNA in lung cancer. This paper also summarizes the recent advances in circRNA biogenesis, analyzes the role of circRNAs in cancers, and discusses the potential mechanisms of circRNAs in lung cancer.

Keywords: Back-splicing; Biomarker; Circular RNA; Lung cancer; MicroRNA sponge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing
  • Exons / genetics
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / therapy*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Models, Genetic
  • RNA / classification
  • RNA / genetics*
  • RNA / metabolism
  • RNA Precursors / genetics
  • RNA Precursors / metabolism
  • RNA, Circular
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism

Substances

  • MicroRNAs
  • RNA Precursors
  • RNA, Circular
  • RNA, Untranslated
  • RNA