Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules

Bioconjug Chem. 2018 May 16;29(5):1485-1489. doi: 10.1021/acs.bioconjchem.7b00820. Epub 2018 Apr 13.

Abstract

We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cross-Linking Reagents / chemistry
  • Delayed-Action Preparations / chemistry*
  • Humans
  • Muramidase / administration & dosage
  • Nanoparticles / chemistry*
  • Pharmaceutical Preparations / administration & dosage*
  • Photolysis*
  • Polymers / chemistry*
  • Proteins / administration & dosage*
  • Ultraviolet Rays

Substances

  • Cross-Linking Reagents
  • Delayed-Action Preparations
  • Pharmaceutical Preparations
  • Polymers
  • Proteins
  • Muramidase