microRNAs in the haemostatic system: More than witnesses of thromboembolic diseases?

Ana B Arroyo; Ascensión M de Los Reyes-García; Raúl Teruel-Montoya; Vicente Vicente; Rocío González-Conejero; Constantino Martínez

doi:10.1016/j.thromres.2018.03.021

microRNAs in the haemostatic system: More than witnesses of thromboembolic diseases?

Thromb Res. 2018 Jun:166:1-9. doi: 10.1016/j.thromres.2018.03.021. Epub 2018 Apr 6.

Authors

Ana B Arroyo¹, Ascensión M de Los Reyes-García¹, Raúl Teruel-Montoya², Vicente Vicente², Rocío González-Conejero³, Constantino Martínez⁴

Affiliations

¹ Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca, Murcia, Spain.
² Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca, Murcia, Spain; Red CIBERER CB15/00055, Murcia, Spain.
³ Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca, Murcia, Spain. Electronic address: rocio.gonzalez@carm.es.
⁴ Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca, Murcia, Spain. Electronic address: constant@um.es.

PMID: 29649766
DOI: 10.1016/j.thromres.2018.03.021

Abstract

MicroRNAs (miRNAs) are small endogenous RNAs that post-transcriptionally regulate gene expression. In the last few years, these molecules have been implicated in the regulation of haemostasis, and an increasing number of studies have investigated their relationship with the development of thrombosis. In this review, we discuss the latest developments regarding the role of miRNAs in the regulation of platelet function and secondary haemostasis. We also discuss the genetic and environmental factors that regulate miRNAs. Finally, we address the potential use of miRNAs as prognostic and diagnostic tools in thrombosis.

Keywords: Biomarkers; Haemostasis; Regulation; Thrombosis; microRNAs.

Publication types

Review

MeSH terms

Genetic Therapy / methods*
Hemostatics / metabolism*
Humans
MicroRNAs / genetics*
Thromboembolism / genetics*
Thromboembolism / therapy

Substances

Hemostatics
MicroRNAs