An efficient protocol for the synthesis of highly sensitive indole imines utilizing green chemistry: optimization of reaction conditions

Bushra Nisar; Syeda Laila Rubab; Abdul Rauf Raza; Sobia Tariq; Ayesha Sultan; Muhammad Nawaz Tahir

doi:10.1007/s11030-018-9826-3

An efficient protocol for the synthesis of highly sensitive indole imines utilizing green chemistry: optimization of reaction conditions

Mol Divers. 2018 Aug;22(3):709-722. doi: 10.1007/s11030-018-9826-3. Epub 2018 Apr 11.

Authors

Bushra Nisar¹, Syeda Laila Rubab², Abdul Rauf Raza³, Sobia Tariq⁴, Ayesha Sultan⁵, Muhammad Nawaz Tahir⁶

Affiliations

¹ Department of Chemistry, The University of Lahore, Sargodha Campus, Lahore Road, Sargodha, 40100, Pakistan.
² Department of Chemistry, University of Education, Jauharabad Campus, Jauharabad, 41200, Pakistan.
³ Ibn e Sina Block, Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan. rauf.raza@uos.edu.pk.
⁴ Ibn e Sina Block, Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
⁵ Department of Chemistry, University of Education, Faisalabad Campus, Faisalabad, 38000, Pakistan.
⁶ Ibn ul Haithum Block, Department of Physics, University of Sargodha, Sargodha, 40100, Pakistan.

PMID: 29644489
DOI: 10.1007/s11030-018-9826-3

Abstract

Novel and highly sensitive indole-based imines have been synthesized. Their synthesis has been compared employing a variety of protocols. Ultimately, a convenient, economical and high yielding set of conditions employing green chemistry have been designed for their synthesis.

Keywords: Green chemistry; Imines; Indole; Schiff bases.

MeSH terms

Green Chemistry Technology
Imines / chemistry*
Indoles / chemistry*

Substances

Imines
Indoles