Guidelines for using animal models in blast injury research

J R Army Med Corps. 2019 Feb;165(1):38-40. doi: 10.1136/jramc-2018-000956. Epub 2018 Apr 10.

Abstract

Blast injury is a very complex phenomenon and frequently results in multiple injuries. One method to investigate the consequences of blast injuries is with the use of living systems (animal models). The use of animals allows the examination and evaluation of injury mechanisms in a more controlled manner, allowing variables such as primary or secondary blast injury for example, to be isolated and manipulated as required. To ensure a degree of standardisation across the blast research community a set of guidelines which helps researchers navigate challenges of modelling blast injuries in animals is required. This paper describes the guidelines for Using Animal Models in Blast Injury Research developed by the NATO Health Factors and Medicine (HFM) Research Task Group 234.

Keywords: blast injuries; guidelines for using animal; injury research.

MeSH terms

  • Animals
  • Biomedical Research / standards*
  • Blast Injuries*
  • Disease Models, Animal*
  • Guidelines as Topic
  • Research Design