Novel antibacterial biodegradable Fe-Mn-Ag alloys produced by mechanical alloying

Mater Sci Eng C Mater Biol Appl. 2018 Jul 1:88:88-94. doi: 10.1016/j.msec.2018.03.005. Epub 2018 Mar 11.

Abstract

Various compositions and synthesis methods of biodegradable iron-based alloys have been studied aiming for the use of temporary medical implants. However, none is focused on nano-structured alloy and on adding antibacterial property to the alloy. In this study, new Fe-30Mn-(1-3)Ag alloys were synthesized by means of mechanical alloying and assessed for their microstructure, mechanical properties, corrosion rate, antibacterial activity and cytotoxicity. Results showed that the alloy with 3 wt% Ag content displayed the highest relative density, shear strength, micro hardness and corrosion rate. However, optimum cytotoxicity and the antibacterial activity were reached by the alloy with 1 wt% Ag content. The compositional and processing effects of the alloys' properties are further discussed in this work.

Keywords: Antibacterial; Biodegradable metal; Cytotoxicity; Fe-Mn alloy; Mechanical alloying.

MeSH terms

  • Absorbable Implants*
  • Alloys* / chemistry
  • Alloys* / pharmacology
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Human Umbilical Vein Endothelial Cells / cytology
  • Human Umbilical Vein Endothelial Cells / metabolism*
  • Humans
  • Iron / chemistry
  • Iron / pharmacology
  • Manganese / chemistry
  • Manganese / pharmacology
  • Materials Testing*
  • Silver / chemistry
  • Silver / pharmacology

Substances

  • Alloys
  • Anti-Bacterial Agents
  • Silver
  • Manganese
  • Iron