One-step fabrication of functionalized poly(etheretherketone) surfaces with enhanced biocompatibility and osteogenic activity

Sidi Liu; Yuting Zhu; Hainan Gao; Peng Ge; Keli Ren; Jingwei Gao; Yupeng Cao; Dong Han; Junhu Zhang

doi:10.1016/j.msec.2018.03.003

One-step fabrication of functionalized poly(etheretherketone) surfaces with enhanced biocompatibility and osteogenic activity

Mater Sci Eng C Mater Biol Appl. 2018 Jul 1:88:70-78. doi: 10.1016/j.msec.2018.03.003. Epub 2018 Mar 10.

Authors

Sidi Liu¹, Yuting Zhu², Hainan Gao³, Peng Ge³, Keli Ren⁴, Jingwei Gao⁴, Yupeng Cao⁴, Dong Han⁵, Junhu Zhang⁶

Affiliations

¹ National Center for Nanoscience and Technology, Beijing 100190, PR China; State Key Laboratory of Supramolecular Structure and Materials, Department of Chemistry, Jilin University, Changchun 130012, PR China.
² Wuhan University of Science and Technology, Wuhan, Hubei, PR China.
³ State Key Laboratory of Supramolecular Structure and Materials, Department of Chemistry, Jilin University, Changchun 130012, PR China.
⁴ National Center for Nanoscience and Technology, Beijing 100190, PR China.
⁵ National Center for Nanoscience and Technology, Beijing 100190, PR China. Electronic address: dhan@nanoctr.cn.
⁶ State Key Laboratory of Supramolecular Structure and Materials, Department of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: zjh@jlu.edu.cn.

PMID: 29636140
DOI: 10.1016/j.msec.2018.03.003

Abstract

Polyetheretherketone (PEEK) has an elastic modulus similar to that of the bone; however, its use as a material for bone repair is limited by bio-inert surface chemistry and poor osteogenesis-inducing capacity. To address this issue, the PEEK surface was activated by ultraviolet radiation-induced grafting of methacrylated hyaluronic acid (MeHA) and titanium dioxide (TiO₂) nanofibers via a one-step process. The modified PEEK surface was characterized by X-ray photoelectron and Fourier-transform infrared spectroscopy, and the extent of surface modification was evaluated by measuring static contact angles. Atomic force microscopy revealed that the PEEK surface grafted with electrospun TiO₂ had abundant nanofibers and a roughness that was comparable to that of human cortical bone. In vitro experiment, rat bone mesenchymal stem cells showed increased adhesion, proliferation, and osteogenic differentiation capacity on TiO₂-modified as compared to unmodified PEEK. Thus, PEEK that is surface-modified with electrospun TiO₂ and MeHA has enhanced biocompatibility and can be an effective material for use in orthopedic implants and medical devices.

Keywords: Biocomposites; Methacrylated hyaluronic acid; Osteogenic differentiation; Polyetheretherketone; Titanium dioxide electrospun.

MeSH terms

Animals
Benzophenones
Cell Adhesion / drug effects
Cell Differentiation
Coated Materials, Biocompatible* / chemistry
Coated Materials, Biocompatible* / pharmacology
Ketones* / chemistry
Ketones* / pharmacology
Male
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / metabolism*
Nanofibers / chemistry*
Osteogenesis / drug effects*
Polyethylene Glycols* / chemistry
Polyethylene Glycols* / pharmacology
Polymers
Rats
Rats, Wistar
Titanium* / chemistry
Titanium* / pharmacology

Substances

Benzophenones
Coated Materials, Biocompatible
Ketones
Polymers
titanium dioxide
polyetheretherketone
Polyethylene Glycols
Titanium