Aim: This study evaluated the antiobesity effect of skim milk prepared with conjugated linoleic acid producing probiotic Lactobacillus fermentum DDHI27 (PCLA).
Materials & methods: C57BL/6 J mice were divided into five groups, and different obesity-associated parameters were studied.
Results: PCLA supplementation alleviated body weight, epididymal and mesenteric fats and improves lipid profiles. Significant ameliorations in leptin, blood glucose, hepatic steatosis and reduction in adipocytes size were also observed. Additionally, feeding also led to positive alterations in the adipogenesis transcription factors and key lipogenesis genes. Improvement in the gut microbiota dysbiosis was also revealed.
Conclusion: Results inferred that PCLA exerted an antiobesity effect in diet-induced obese mice and may be further developed in the functional foods for the management of obesity.
Keywords: ACC; C/EBPα; FAS; PPARγ; SERBP-1c; UCP-2; conjugated linoleic acid; functional foods; liver steatosis; skim milk.