An uncommon case of chronic myeloid leukemia with variant cytogenetic

Acta Biomed. 2018 Apr 3;89(3-S):28-32. doi: 10.23750/abm.v89i3-S.7217.

Abstract

Chronic Myeloid Leukemia (CML) is myeloproliferative neoplasm characterized by Philadelphia chromosome which is a balanced translocation between chromosome 9 and 22 in 90% of cases. However, variant cytogenetic still happens in 5-10 % of cases, the importance of which is controversial as well as its response to therapy, prognosis and progression to acute leukemias. Here we report a male patient with CML and variant cytogenetic who responded to low dose of Dasatinib (50 mg daily).

Publication types

  • Case Reports

MeSH terms

  • Abnormal Karyotype*
  • Antineoplastic Agents / therapeutic use
  • Bone Marrow / pathology
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 17 / ultrastructure
  • Chromosomes, Human, Pair 22 / genetics
  • Chromosomes, Human, Pair 22 / ultrastructure
  • Chromosomes, Human, Pair 9 / genetics
  • Chromosomes, Human, Pair 9 / ultrastructure
  • Dasatinib / therapeutic use
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Male
  • Middle Aged
  • Molecular Targeted Therapy
  • Protein Kinase Inhibitors / therapeutic use
  • Translocation, Genetic*

Substances

  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • Dasatinib