Hypercalcemia and acute pancreatitis in a male patient with acute promyelocytic leukemia and pulmonary tuberculosis

Acta Biomed. 2018 Apr 3;89(3-S):23-27. doi: 10.23750/abm.v89i3-S.7216.

Abstract

We report a rare case of hypercalcemia and acute pancreatitis in a subject with acute promyelocytic leukemia (APL) and pulmonary tuberculosis, during all-trans-retinoic acid (ATRA) treatment. Both associated complications were potentially due to several causes. A careful monitoring and exclusion of all causative factors must be addressed. Further research is necessary to improve our understanding of risk factors for these complications in patients with (APL). Studying these patterns may help us to improve outcomes for all children and young adults with hematologic malignancies.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asparaginase / administration & dosage
  • Asparaginase / adverse effects
  • Causality
  • Febrile Neutropenia / chemically induced
  • Humans
  • Hypercalcemia / etiology*
  • Leukemia, Promyelocytic, Acute / complications*
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Male
  • Mercaptopurine / administration & dosage
  • Mercaptopurine / adverse effects
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Middle Aged
  • Models, Biological
  • Pancreatitis / etiology*
  • Pleural Effusion / etiology
  • Prednisone / administration & dosage
  • Prednisone / adverse effects
  • Pulmonary Aspergillosis / complications
  • Risk Factors
  • Tretinoin / administration & dosage
  • Tretinoin / adverse effects
  • Tuberculosis, Pulmonary / complications*
  • Vincristine / administration & dosage
  • Vincristine / adverse effects

Substances

  • Tretinoin
  • Vincristine
  • Mercaptopurine
  • Asparaginase
  • Prednisone
  • Methotrexate

Supplementary concepts

  • CCG-141 protocol