The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women

Abbass Ghanbari-Niaki; Ayoub Saeidi; Mehdi Ahmadian; Leila Gharahcholo; Nooshin Naghavi; Mohammad Fazelzadeh; Soleiman Mahjoub; Stephen Myers; Andrew Williams

doi:10.1016/j.imr.2018.01.007

The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women

Integr Med Res. 2018 Mar;7(1):44-52. doi: 10.1016/j.imr.2018.01.007. Epub 2018 Jan 31.

Authors

Abbass Ghanbari-Niaki¹, Ayoub Saeidi¹, Mehdi Ahmadian², Leila Gharahcholo¹, Nooshin Naghavi³, Mohammad Fazelzadeh⁴, Soleiman Mahjoub^{5

6}, Stephen Myers⁷, Andrew Williams⁷

Affiliations

¹ Exercise Biochemistry Division, Faculty of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran.
² Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran.
³ Medical School of Osaka City University, Japan.
⁴ Exercise Biochemistry Division, Faculty of Physical Education and Sport Sciences, Birjand University, Birjand, South Khorasan, Iran.
⁵ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁶ Based Health Products Research Center, Health Research Institute, Babol University of Medical Sciences. Babol, Iran.
⁷ School of Health Sciences, University of Tasmania, Launceston, Australia.

Abstract

Background: We examined the effect of antioxidant supplementation and exercise on irisin within postmenopausal women.

Methods: Forty-eight participants (age: 55.7 ± 4.9 years; weight: 68.0 ± 6.3 kg; BMI 27.0 ± 2.7; mean ± SD) were randomized into four groups for the eight week intervention: control group (CG; n = 12), resistance training group (RTG; n = 12), supplementation with Zataria multiflora group (ZG; n = 12), or supplementation with Z. multiflora and resistance training group (ZRTG; n = 12). RTG and ZRTG performed circuit resistance training, and both ZG and ZRTG consumed 500 mg of Z. multiflora every day during the intervention. Blood samples were taken 48 hours before and after the intervention.

Results: There was a significant difference in irisin at post-training, with greater levels in ZRTG compared to CG. A significant increase was noted for irisin at post-training compared to pre-training for ZG, RTG, and ZRTG. Moreover, we identified a significant decrease in malondialdehyde in the RTG and ZRTG groups and increase in glutathione in the ZG, RTG, and ZRTG groups when compared to CG.

Conclusion: These findings showed that exercise, Z. multiflora supplementation or their combination led to an increase in irisin.

Keywords: Antioxidants; Circuit resistance training; Myokine; Postmenopausal women; Zataria multiflora.