Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution

Song Ding; Colin P O'Banion; Joshua G Welfare; David S Lawrence

doi:10.1016/j.chembiol.2018.03.003

Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution

Cell Chem Biol. 2018 Jun 21;25(6):648-658. doi: 10.1016/j.chembiol.2018.03.003. Epub 2018 Apr 5.

Authors

Song Ding¹, Colin P O'Banion¹, Joshua G Welfare², David S Lawrence³

Affiliations

¹ Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
² Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
³ Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: lawrencd@email.unc.edu.

PMID: 29628434
DOI: 10.1016/j.chembiol.2018.03.003

Abstract

Cell-based drug delivery systems offer the prospect of biocompatibility, large-loading capacity, long in vivo lifespan, and active targeting of diseased sites. However, these opportunities are offset by an array of challenges, including safeguarding the integrity of the drug cargo and the cellular host, as well as ensuring that drug release occurs at the appropriate time and place. Emerging strategies that address these, and related, issues, are described herein.

Keywords: cellular carriers; drug delivery; drug loading; drug release.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocompatible Materials / chemistry
Biocompatible Materials / pharmacology*
Drug Carriers / chemistry
Drug Delivery Systems / methods*
Drug Delivery Systems / trends*
Erythrocytes / chemistry
Erythrocytes / drug effects*
Erythrocytes / metabolism
Humans
Neural Stem Cells / chemistry
Neural Stem Cells / drug effects*
Neural Stem Cells / metabolism

Substances

Biocompatible Materials
Drug Carriers