Development of electrosprayed mucoadhesive chitosan microparticles

Jorge Alberto S Moreno; Ana C Mendes; Karen Stephansen; Christoph Engwer; Francisco M Goycoolea; Anja Boisen; Line Hagner Nielsen; Ioannis S Chronakis

doi:10.1016/j.carbpol.2018.02.062

Development of electrosprayed mucoadhesive chitosan microparticles

Carbohydr Polym. 2018 Jun 15:190:240-247. doi: 10.1016/j.carbpol.2018.02.062. Epub 2018 Feb 24.

Authors

Jorge Alberto S Moreno¹, Ana C Mendes², Karen Stephansen¹, Christoph Engwer³, Francisco M Goycoolea⁴, Anja Boisen⁵, Line Hagner Nielsen⁶, Ioannis S Chronakis¹

Affiliations

¹ Nano-Bio Science Research Group, DTU Food, Technical University of Denmark, Kemitorvet 202, 2800 Kgs, Lyngby, Denmark.
² Nano-Bio Science Research Group, DTU Food, Technical University of Denmark, Kemitorvet 202, 2800 Kgs, Lyngby, Denmark. Electronic address: anac@food.dtu.dk.
³ Institute of Plant Biotechnology and Biology, University of Münster, Schlossplatz 8, 48143, Münster, Germany.
⁴ Institute of Plant Biotechnology and Biology, University of Münster, Schlossplatz 8, 48143, Münster, Germany; School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, United Kingdom.
⁵ Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads 345C, 2800 Kgs, Lyngby, Denmark.
⁶ Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads 345C, 2800 Kgs, Lyngby, Denmark. Electronic address: lihan@nanotech.dtu.dk.

PMID: 29628244
DOI: 10.1016/j.carbpol.2018.02.062

Abstract

The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.

Keywords: Chitosan; Electrohydrodynamics; Electrospray; Microparticles; Mucoadhesion; Polysaccharide.