CYP1A1 gene polymorphisms modify the association between PM10 exposure and lung function

Abstract

Genetic epidemiological studies have provided evidence that several genes modify the link between air pollution and lung function. We assessed whether the adverse impacts of particulate matter with an aerodynamic diameter ≤10 μm (PM₁₀) on lung function are modified by CYP1A1 gene polymorphisms in Korean adults. We used health check-up data from 1817 men, and the annual mean concentrations of ambient PM₁₀ estimated from the ambient data. Three single nucleotide polymorphisms (SNPs) of CYP1A1 were selected for our study. We identified significant CYP1A1 SNPs-by-PM₁₀ interactions for forced expiratory volume 1 s (FEV₁) and forced vital capacity (FVC) (all p_int < 0.05). Minor allele carriers of the SNPs were more susceptible to PM₁₀-induced FEV₁ and FVC reduction. The subgroup analysis of SNP genotypes showed that no significant association between PM₁₀ and FEV₁ or FVC was observed in homozygous reference genotype groups of all SNPs (all p_assoc > 0.05), whereas in heterozygous or homozygous alternate genotype groups, PM₁₀ was significantly associated with decreased FEV₁ (all p_assoc for FEV₁ < 0.05). The association between persistent exposure to PM₁₀ and lung function decline in Korean men may be determined in part by several functional variants of the CYP1A1 gene.

Keywords: Cytochrome P-450 CYP1A1; Interaction; Lung function; Particulate matter; Polymorphism.