Abstract
Two new lignans named neourticol A (1) and neourticol B (2), together with seven known compounds (3-9), were isolated from Urticae Fissae Herba, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1 and 2 possessed the potent anti-complement and anti-inflammatory activities.
Keywords:
Urticaceae; anti-complement; anti-inflammation; secolignan.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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China
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Lignans / chemistry*
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Lignans / pharmacology*
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Medicine, Chinese Traditional
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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RAW 264.7 Cells
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Tumor Necrosis Factor-alpha / metabolism
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Urticaceae / chemistry*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lignans
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Plant Extracts
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Tumor Necrosis Factor-alpha
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Nitric Oxide