Germ-line configuration of the T-cell receptor beta-chain gene in B-cell chronic lymphoproliferative disorders which co-express T-cell antigens

Eur J Haematol. 1987 Nov;39(5):412-7. doi: 10.1111/j.1600-0609.1987.tb01448.x.

Abstract

In 7 cases of chronic B-cell lymphoproliferative disorders-6 chronic lymphocytic leukaemias and 1 non-Hodgkin lymphoma in leukaemic phase--which co-expressed T-cell markers (CD3, CD2) the clonal origin was investigated at the DNA level. In accordance with the diagnosis, all cases showed a monoclonally rearranged configuration of the immunoglobulin genes. On the contrary, the T-cell receptor beta chain gene always retained a germ-line organization. These findings demonstrate that B-cell chronic lymphoproliferative disorders which co-express T-cell-related markers are truly composed of monoclonal B-cell elements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Differentiation, T-Lymphocyte / analysis*
  • Antigens, Neoplasm / analysis*
  • B-Lymphocytes / immunology*
  • Clone Cells / immunology
  • Genes, Immunoglobulin*
  • Humans
  • Leukemia, Lymphoid / genetics*
  • Leukemia, Lymphoid / immunology
  • Lymphoma, Non-Hodgkin / genetics*
  • Lymphoma, Non-Hodgkin / immunology
  • Phenotype
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta