Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation

Weifu Kong; Jiaxun Wan; Supawadee Namuangruk; Jia Guo; Changchun Wang

doi:10.1038/s41598-018-23744-1

Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation

Sci Rep. 2018 Apr 3;8(1):5529. doi: 10.1038/s41598-018-23744-1.

Authors

Weifu Kong¹, Jiaxun Wan¹, Supawadee Namuangruk², Jia Guo³, Changchun Wang¹

Affiliations

¹ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P.R. China.
² National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Pathumthani, 12120, Thailand.
³ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P.R. China. guojia@fudan.edu.cn.

Abstract

An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Availability
Cattle
Cell Survival
Clathrin / metabolism*
Coated Pits, Cell-Membrane / metabolism*
Endocytosis*
Hep G2 Cells
Humans
Metal-Organic Frameworks / chemistry*
Metals / chemistry*
Protein Transport
Serum Albumin, Bovine / chemistry
Serum Albumin, Bovine / metabolism*
Solubility
Water

Substances

Clathrin
Metal-Organic Frameworks
Metals
Water
Serum Albumin, Bovine