Multistimuli Responsive Core-Shell Nanoplatform Constructed from Fe3 O4 @MOF Equipped with Pillar[6]arene Nanovalves

Ming-Xue Wu; Jia Gao; Fang Wang; Jie Yang; Nan Song; Xiaoyu Jin; Peng Mi; Jian Tian; Jiayan Luo; Feng Liang; Ying-Wei Yang

doi:10.1002/smll.201704440

Multistimuli Responsive Core-Shell Nanoplatform Constructed from Fe₃ O₄ @MOF Equipped with Pillar[6]arene Nanovalves

Small. 2018 Apr;14(17):e1704440. doi: 10.1002/smll.201704440. Epub 2018 Apr 3.

Authors

Ming-Xue Wu¹, Jia Gao¹, Fang Wang², Jie Yang¹, Nan Song¹, Xiaoyu Jin¹, Peng Mi², Jian Tian³, Jiayan Luo⁴, Feng Liang⁵, Ying-Wei Yang¹

Affiliations

¹ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
² State Key Laboratory of Biotherapy and Cancer Center and Department of Cardiovascular Surgery, West China Hospital, Collaborative Innovation Centre for Biotherapy, Sichuan University, 17 Renmin South Road, Sichuan, 610041, P. R. China.
³ Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
⁴ Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300072, P. R. China.
⁵ The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, P. R. China.

PMID: 29611291
DOI: 10.1002/smll.201704440

Abstract

An intelligent theranostic nanoplatform based on nanovalve operated metal-organic framework (MOF) core-shell hybrids, incorporating tumorous microenvironment-triggered drug release, magnetic resonance imaging (MRI) guidance, sustained release, and effective chemotherapy in one pot is reported. The core-shell hybrids are constructed by an in situ growth method, in which Fe₃ O₄ particles with superior abilities of MRI and magnetic separation form the core and UiO-66 MOF with high loading capacity compose the shell, and then are surface-installed with pillararene-based pseudorotaxanes as tightness-adjustable nanovalves. This strategy endows the system with the ability of targeted, multistimuli responsive drug release in response to pH changes, temperature variations, and competitive agents. Water-soluble carboxylatopillar[6]arene system achieved sustained drug release over 7 days due to stronger host-guest binding, suggesting that the nanovalve tightness further reinforces the desirable release of anticancer agent over a prolonged time at the lesion site.

Keywords: Zn2+ triggers; mechanized metal-organic frameworks; pillarene; supramolecular switches; targeted drug release.

Publication types

Research Support, Non-U.S. Gov't