With the widely application of the metagenomics, the relationship between microbiota and disease has become a hot research topic. Understanding the potential association between upper gastrointestinal cancer or precancerous lesions and microbiota may play an important role in the early detection, clinical diagnosis and treatment, and prognostic evaluation of upper gastrointestinal cancer. Therefore, a literature retrieval was conducted by using PubMed, Embase and wanfang databases to summarize the latest research progress in the microbiota of upper gastrointestinal cancer, including oral, esophageal, gastric cancer and precancerous lesions. Lower microbial diversity or richness in esophageal cancer and precancerous lesions and specific prognostic biomarkers for esophageal cancer were found. Lactobacillus richness showed an increase trend during the process from gastritis to gastric cancer. This paper summarizes the progress in the research of potential biological etiology of upper gastrointestinal cancer from the perspective of metagenomics in order to provide evidence on the, prevention and control of upper gastrointestinal cancer.
随着宏基因组学的广泛应用，微生物菌群与疾病相关性研究已成为研究热点。深入探讨上消化道癌及其癌前病变与微生物菌群间的潜在关联，对于上消化道癌早诊早治、临床诊疗、预后评估均有重要意义。本文通过查阅PubMed、Embase、万方数据平台等数据库文献，对目前口腔癌、食管癌和胃癌及其癌前病变与微生物菌群研究现况进行了总结，发现食管癌及癌前病变菌群多样性或丰度普遍降低，且牙龈卟啉单胞菌和具核酸杆菌可作为食管癌预后的标记物；胃癌前病变进展为癌的过程中，乳杆菌丰度呈升高趋势。本文从宏基因组学的角度综述了上消化道癌潜在生物学病因研究方面的进展，以期为探索上消化道癌的发病机制和预防控制提供科学依据。.
Keywords: Metagenomics; Microbiota; Precancerous lesion; Upper gastrointestinal cancer.