Recent advances on production of 2, 3-butanediol using engineered microbes

Zhiliang Yang; Zisheng Zhang

doi:10.1016/j.biotechadv.2018.03.019

Recent advances on production of 2, 3-butanediol using engineered microbes

Biotechnol Adv. 2019 Jul-Aug;37(4):569-578. doi: 10.1016/j.biotechadv.2018.03.019. Epub 2018 Mar 31.

Authors

Zhiliang Yang¹, Zisheng Zhang²

Affiliations

¹ Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis Pasteur Private, Ottawa, ON K1N 6N5, Canada. Electronic address: zyang079@uottawa.ca.
² Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis Pasteur Private, Ottawa, ON K1N 6N5, Canada. Electronic address: zzhang@uottawa.ca.

PMID: 29608949
DOI: 10.1016/j.biotechadv.2018.03.019

Abstract

As a significant platform chemical, 2, 3-butanediol (2, 3-BD) has found wide applications in industry. The success of microbial 2, 3-BD production was limited by the use of pathogenic microorganisms and low titer in engineered hosts. The utilization of cheaply available feedstock such as lignocellulose was another major challenge to achieve economic production of 2, 3-BD. To address those issues, engineering strategies including both genetic modifications and process optimization have been employed. In this review, we summarized the state-of-the-art progress in the biotechnological production of 2, 3-BD. Metabolic engineering and process engineering strategies were discussed.

Keywords: 2, 3-Butanediol; Butanediol dehydrogenase; Metabolic engineering; Process engineering; Renewable energy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Butylene Glycols / chemistry*
Fermentation
Glucose / chemistry
Lignin / chemistry
Metabolic Engineering*

Substances

Butylene Glycols
lignocellulose
2,3-butylene glycol
Lignin
Glucose