Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Masafumi Hidaka; Keita Kosaka; Saori Tsushima; Chiyoko Uchida; Katsuhiko Takahashi; Noriko Takahashi; Masayoshi Tsubuki; Yukihiko Hara; Takafumi Uchida

doi:10.1016/j.bbrc.2018.03.212

Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Biochem Biophys Res Commun. 2018 May 15;499(3):681-687. doi: 10.1016/j.bbrc.2018.03.212. Epub 2018 Apr 3.

Authors

Masafumi Hidaka¹, Keita Kosaka¹, Saori Tsushima¹, Chiyoko Uchida², Katsuhiko Takahashi³, Noriko Takahashi⁴, Masayoshi Tsubuki⁵, Yukihiko Hara⁶, Takafumi Uchida⁷

Affiliations

¹ Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba, Sendai, Miyagi, 980-0845, Japan.
² Department of Human Development and Culture, Fukushima University, Fukushima, Fukushima, 960-1296, Japan.
³ Laboratory of Biochemistry, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo, 142-8501, Japan.
⁴ Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo, 142-8501, Japan.
⁵ Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo, 142-8501, Japan.
⁶ Tea Solutions, Hara Office Inc., 1-18-15-510, Taihei, Sumida-Ku, Tokyo 130-0012, Japan.
⁷ Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba, Sendai, Miyagi, 980-0845, Japan. Electronic address: uchidataka@gmail.com.

PMID: 29608894
DOI: 10.1016/j.bbrc.2018.03.212

Abstract

We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.

Keywords: Caffeic acid; EGCG; Food polyphenols; Pin1; Prolyl isomerase; Tannic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caffeic Acids / chemistry
Caffeic Acids / pharmacology
Catechin / chemistry
Catechin / pharmacology
Food*
HCT116 Cells
Humans
NIMA-Interacting Peptidylprolyl Isomerase / antagonists & inhibitors*
NIMA-Interacting Peptidylprolyl Isomerase / metabolism
Polyphenols / chemistry
Polyphenols / pharmacology*
Quercetin / chemistry
Quercetin / pharmacology
Rutin / chemistry
Rutin / pharmacology
Tannins / chemistry
Tannins / pharmacology

Substances

Caffeic Acids
NIMA-Interacting Peptidylprolyl Isomerase
Polyphenols
Tannins
Rutin
Catechin
Quercetin
caffeic acid