Magnetic solid-phase extraction based on magnetic zeolitic imazolate framework-8 coupled with high performance liquid chromatography for the determination of polymer additives in drinks and foods packed with plastic

Abstract

In this study, magnetic zeolitic imazolate framework-8 (Fe₃O₄@ZIF-8) was successfully synthesized by a typical hydrothermal method. The facile magnetic solid-phase extraction (MSPE) based on Fe₃O₄@ZIF-8 was proposed for concentrating polymer additives (antioxidants and ultraviolet absorbers). The conditions of MSPE process were optimized. An analytical method of magnetic solid-phase extraction followed by high performance liquid chromatography (MSPE-HPLC) was successfully established for the simultaneous determination of seven polymer additives in drinks and foods packed with plastic. The established method showed good precision, reproducibility, stability, and accuracy with the low limits of detection (0.03-0.15 ng/mL) and limits of quantification (0.08-0.50 ng/mL). The results of this study indicated the Fe₃O₄@ZIF-8 coupled with HPLC provided an efficient enrichment and determination method for polymer additives in drinks and foods.

Keywords: Food safety; High performance liquid chromatography; Magnetic solid-phase extraction; Magnetic zeolitic imazolate framework-8; Plastic packaging; Polymer additives.