Transport Barriers and Oncophysics in Cancer Treatment

Trends Cancer. 2018 Apr;4(4):277-280. doi: 10.1016/j.trecan.2018.02.008. Epub 2018 Mar 15.

Abstract

Transport processes in cancer are the focus of transport oncophysics (TOP). In the TOP approach, the sequential negotiation of transport barriers is critical to both drug delivery and metastasis development. New and creative therapeutic opportunities are currently emerging, stimulated by the study of cancer hallmarks with the TOP approach.

Keywords: biophysical markers; drug partitioning; drug transport; transport barriers; transport oncophysics; transport phenotype.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Biological Transport / drug effects
  • Biomarkers, Tumor / analysis
  • Biophysics / methods*
  • Biophysics / trends
  • Drug Delivery Systems*
  • Drug Resistance, Neoplasm
  • Endothelium / drug effects
  • Endothelium / pathology
  • Humans
  • Medical Oncology / methods*
  • Medical Oncology / trends
  • Nanomedicine / methods
  • Nanomedicine / trends
  • Neoplasms / blood supply
  • Neoplasms / drug therapy*
  • Neoplasms / etiology
  • Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor