A novel biphenyl-derived salicylhydrazone Schiff base fluorescent probes for identification of Cu2+ and application in living cells

Abstract

A novel biphenyl-derived salicylhydrazone Schiff base (BSS) fluorescent probes for highly sensitive and selective identification of Cu²⁺ has been synthesized. In addition, the recognition has been proved experimentally. The results indicated that the complex forms a 1:1 complex with Cu²⁺ shows fluorescent quenching. Furthermore, the detection limit of 1.54×10^-8M. More interesting, the probe BSS not only have a good biocompatibility in living cells, but also the sense behavior of Cu²⁺ in the cell nucleus.

Keywords: Cu(2+); Fluorescence; Identification; Salicylhydrazone Schiff base.