Genomic Pathology and Cancer Biomarkers: Prostate Cancer

Crit Rev Oncog. 2017;22(5-6):515-525. doi: 10.1615/CritRevOncog.2017020539.

Abstract

Our understanding of genomic pathology and biomarkers for prostate cancer is continually growing. Some promising and useful tissue markers are GSTP1, HOXD3, cell cycle proteins, chromatin remodeling proteins, androgen receptor, Stat5a/b, ERG, and PTEN. Serum and urine markers are mostly either prostate-specific antigen or newer tests using one or more other kallikreins or sarcosine. The data and evidence for all of these markers and the commercial tests using them are reviewed here.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor* / blood
  • Biomarkers, Tumor* / urine
  • Genomics
  • Glutathione S-Transferase pi / blood
  • Glutathione S-Transferase pi / urine
  • Homeodomain Proteins / blood
  • Homeodomain Proteins / urine
  • Humans
  • Kallikreins / blood
  • Kallikreins / urine
  • Male
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / blood*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / urine*
  • Transcription Factors

Substances

  • Biomarkers, Tumor
  • Homeodomain Proteins
  • Transcription Factors
  • HOXA4 protein, human
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Kallikreins
  • Prostate-Specific Antigen